Description
Zolid Tablets 15mg 14 tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Pioglitazone HCl
Used For
Diabetes
How it works
Pioglitazone is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPAR?). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR? nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.
Usage And Safety
Dosage
Monotherapy : Adults 15-30 mg once daily , increasing to 45mg once daily if necessary . Combination Therapy : Adults 15-30mg once daily , increasing to 45mg once daily if necessary, in combination with current dose of metformin or sulphonylureas. Children : Not Recommended. Always consult your physician or pharmacist for dose adjustment.
Side Effects
Very Common : Hypoglycaemia, edema.Common : Visual disturbances, upper respiratory tract infection, weight increase, hypoaesthesia, anemia, arthralgia, headache, haematuria, erectile dysfunction, flatulence, dizziness, blood creatine phosphokinase increase, bronchitis, back pain, dyspnoea, heart failure.Rare : Sinusitis, flatulence, vertigo, fatigue, increased lactic dehydrogenase, appetite increased, hypoglycaemia, headache, glycosuria, proteinuria, sweating.
Drug Interactions
Midazolam , Gemfibrozil , Rifampicin.
Indication
It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
When not to Use
Pioglitazone is contraindicated in patients with: • Hypersensitivity to the active substance or to any of the excipients. • Cardiac failure or history of cardiac failure (NYHA stages I to IV). • Hepatic impairment • Diabetic ketoacidosis.
Precautions
Precaution
Pioglitazone exerts its antihyperglycemic effect only in the presence of insulin. Therefore, pioglitazone should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
Warnings
Warning 1
Patients receiving pioglitazone in combination with insulin or oral hypoglycemic agents may be at risk for hypoglycemia, and a reduction in the dose of the concomitant agent may be necessary.
Warning 2
Pioglitazone may cause decreases in hemoglobin and hematocrit.
Warning 3
Dose related weight gain may occur with pioglitazone alone and in combination with other hypoglycemic agents.
Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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