Description
Tasmi-AM Tablets 10mg + 80mg 14 Tablets Specification
Requires Prescription (YES/NO)
Yes
Generics
Telmisartan + Amlodipine (As besylate)
Used For
Hypertension
How it works
Amlodipine : Amlodipine inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle. It inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure. Telmisartan : Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis
Usage And Safety
Dosage
Amlodipine + Telmisaratan is effective in the treatment of hypertension in once daily doses of amlodipine as 2.5mg to 10mg and telmisartan as 20mg to 80mg. It may be taken with or without food. Always consult your doctor or pharmacist for dose adjustment.
Side Effects
Common Dizziness and peripheral edema. Uncommon Somnolence, migraine, headache, paraesthesia, vertigo, bradycardia, palpitations, hypotension, orthostatic hypotension, flushing, cough, abdominal pain, diarrhea, nausea, pruritis, arthralgia, muscle spasms (cramps in legs), myalgia, erectile dysfunction, asthenia, chest pain, fatigue, edema and increased hepatic enzymes. Rare Cystitis, depression, anxiety, insomnia, syncope, peripheral neuropathy, hypoaesthesia, dysgeusia, tremor, vomiting, gingival hypertrophy, dyspepsia, dry mouth, eczema, erythema, rash, back pain in extremity (leg pain), nocturia, malaise and increase blood uric acid.
Drug Interactions
Other antihypertensive medicinal products : Concomitant use of other antihypertensive medicinal products can increase the blood pressure lowering effects of the combination of amlodipine and telmisartan tablets. Medicinal products with blood pressure lowering potential : Concomitant use of medicinal products e.g; baclofen, amifostine, neuroleptics or antidepressants may potentiate the hypotensive effects of all antihypertensives including the combination of amlodipine and telmisartan tablets. Corticosteroids : Co-administration of the combination of amlodipine and telmisartan with corticosteroids causes reduction of the antihypertensive effect. Potassium sparing diuretics or Potassium supplements : Concomitant use of angiotensin II receptor antagonists such as telmisartan with potassium sparing diuretics or potassium supplements may attenuate diuretic induced potassium loss. Lithium : Concomitant administration of angiotensin II receptor antagonists including telmisartan with lithium causes reversible increases in serum lithium concentrations and toxicity. Non-steroidal anti-inflammatory medicines : Co-adminstration of NSAID’s (i.e. acetyl salicylic acid at anti-inflammatory dosage regimen, COX-2 inhibitors and non-selective NSAID’s) may reduce the antihypertensive effect of angiotensin II receptor antagonists. CYP3A4 Inhibitors : Co-administration of amlodipine with CYP3A4 inhibitors like erythromycin in young patients and diltiazem in elderly patients respectively increases the plasma concentration of amlodipine by 22% and 50% respectively. The strong inhibitors of CYP3A4 (i.e. ketoconazole, itraconazole, ritonavir) may increase the plasma concentration of amlodipine to a greater extent than diltiazem. CYP3A4 inducers : Concomitant use of amlodipine with CYP3A4 inducers (i.e; rifampicin, Hypericum perforatum) may lead to reduced plasma concentrations of amlodipine.
Indication
Amlodipine + Telmisartan is indicated for : The treatment of hypertension alone or with other antihypertensive agents . The initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals .
When not to Use
The combination of amlodipine and telmisartan is contraindicated in patients who are hypersensitive to the active substances, to dihydropridine derivatives, or to any of the excipients.
Precautions
Precaution
In patients with an activated renin-angiotensin system such as volume or salt-depleted patients (e.g; patients receiving high doses of diuretics) symptomatic hypotension may occur after initiation of therapy with combination of amlodipine and telmisartan tablets. Correction of this condition prior to administration of this combination or close medical supervision at the start of treatment with reduced dose is recommended.
Warnings
Warning 1
Close monitoring is required when administering amlodipine in patients with severe aortic stenosis as it may cause acute hypotension.
Warning 2
Particular caution should be exercised when administering the combination of amlodipine and telmisartan to patients with hepatic insufficiency or biliary obstructive disorders.
Warning 3
Hyperkalemia may occur with angiotensin receptors blockers like telmisartan, particularly in patients with advanced renal impairment, heart failure, on renal replacement therapy, or on drugs that increase potassium levels. Periodic determinations of serum electrolytes are recommended to detect possible electrolyte imbalances, particularly in patients at risk
Additional Information
Pregnancy category
Always consult your physician before using any medicine.
Storage (YES/NO)
Store this medicine at room temperature, away from direct light and heat.
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